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How many of the following items given in box, are favourable for dissociation of oxygen from the oxyhaemoglobin?

Low pCO2, Low pO2, High H+ concentration, Low temperature, High concentration of 2,3 BPG

TRANSPORT OF GASES
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1

Five

2

Three

3

Four

4

Two

Solution:

The dissociation of oxygen from oxyhaemoglobin is influenced by several factors, which cause a shift in the oxygen-haemoglobin dissociation curve to the right, indicating a decreased affinity of haemoglobin for oxygen and thus favouring oxygen release to the tissues.

Let's analyze each factor given:

  1. Low pCO2: A low partial pressure of carbon dioxide (pCO2) increases the affinity of haemoglobin for oxygen, shifting the curve to the left. This is unfavourable for dissociation.

  2. Low pO2: A low partial pressure of oxygen (pO2), as found in tissues, decreases the affinity of haemoglobin for oxygen, promoting its dissociation. This is favourable for dissociation.

  3. High H+ concentration (Low pH): An increase in H+ concentration (i.e., a decrease in pH or increased acidity) reduces the affinity of haemoglobin for oxygen (Bohr effect), favouring dissociation. This is favourable for dissociation.

  4. Low temperature: A low temperature increases the affinity of haemoglobin for oxygen, shifting the curve to the left. This is unfavourable for dissociation.

  5. High concentration of 2,3 BPG (2,3-Bisphosphoglycerate): 2,3-BPG is a metabolic intermediate in red blood cells that binds to haemoglobin and reduces its affinity for oxygen, thereby promoting oxygen release. A high concentration of 2,3-BPG is favourable for dissociation.

Therefore, the factors favourable for the dissociation of oxygen from oxyhaemoglobin are:

  • Low pO2

  • High H+ concentration

  • High concentration of 2,3 BPG

There are three such items.

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